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TargetCoagulation factor X
LigandBDBM50306142
Substrate/Competitorn/a
Meas. Tech.ChEMBL_606078
Ki 0.8±n/a nM
Citation Kleanthous SBorthwick ADBrown DBurns-Kurtis CLCampbell MChaudry LChan CClarte MOConvery MAHarling JDHortense EIrving WRIrvine SPateman AJPatikis ANPinto ILPollard DRRoethka TJSenger SShah GPStelman GJToomey JRWatson NSWest RIWhittaker CZhou PYoung RJ Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs. Bioorg Med Chem Lett 20:618-22 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50306142
n/a
NameBDBM50306142
Synonyms:6-chloro-N-((3S)-1-(4-(1-(ethyl(methyl)amino)ethyl)-2-fluorophenyl)-2-oxopyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL606699
TypeSmall organic molecule
Emp. Form.C25H27ClFN3O3S
Mol. Mass.504.017
SMILESCCN(C)C(C)c1ccc(N2CC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)c(F)c1 |r|
Structure
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