| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Ligand | BDBM50306256 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607027 (CHEMBL1074655) |
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| IC50 | 70±n/a nM |
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| Citation |  Torrisi, C; Bisbocci, M; Ingenito, R; Ontoria, JM; Rowley, M; Schultz-Fademrecht, C; Toniatti, C; Jones, P Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorg Med Chem Lett20:448-52 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Synonyms: | (ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60071.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6F1[R100H] |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM50306256 |
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| n/a |
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| Name | BDBM50306256 |
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| Synonyms: | 1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-1H-benzo[de][1,7]naphthyridin-7(8H)-one | CHEMBL609002 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N4O2 |
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| Mol. Mass. | 322.3611 |
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| SMILES | O=C(CCc1cnccn1)N1CCc2cccc3C(=O)NCC1c23 |
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| Structure | 
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