Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50306292 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_607041 (CHEMBL1074669) |
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IC50 | 16±n/a nM |
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Citation | Liras, S; McHardy, SF; Allen, MP; Segelstein, BE; Heck, SD; Bryce, DK; Schmidt, AW; Vanase-Frawley, M; Callegari, E; McLean, S Biaryl piperidines as potent and selective delta opioid receptor ligands. Bioorg Med Chem Lett20:503-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50306292 |
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n/a |
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Name | BDBM50306292 |
Synonyms: | CHEMBL605735 | N,N-diethyl-4-(3-(3-hydroxyphenyl)-1-(thiazol-2-ylmethyl)piperidin-3-yl)benzamide |
Type | Small organic molecule |
Emp. Form. | C26H31N3O2S |
Mol. Mass. | 449.608 |
SMILES | CCN(CC)C(=O)c1ccc(cc1)C1(CCCN(Cc2nccs2)C1)c1cccc(O)c1 |
Structure |
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