Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50306307 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_609281 (CHEMBL1070042) |
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IC50 | 0.2±n/a nM |
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Citation | Isabel, E; Bateman, KP; Chauret, N; Cromlish, W; Desmarais, S; Duong, le T; Falgueyret, JP; Gauthier, JY; Lamontagne, S; Lau, CK; Léger, S; LeRiche, T; Lévesque, JF; Li, CS; Massé, F; McKay, DJ; Mellon, C; Nicoll-Griffith, DA; Oballa, RM; Percival, MD; Riendeau, D; Robichaud, J; Rodan, GA; Rodan, SB; Seto, C; Thérien, M; Truong, VL; Wesolowski, G; Young, RN; Zamboni, R; Black, WC The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett20:887-92 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50306307 |
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n/a |
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Name | BDBM50306307 |
Synonyms: | (S)-2-((S)-1-(4'-((S)-1-amino-1-oxopropan-2-yl)biphenyl-4-yl)-2,2,2-trifluoroethylamino)-N-(1-cyanocyclopropyl)-4-fluoro-4-methylpentanamide | CHEMBL597426 |
Type | Small organic molecule |
Emp. Form. | C27H30F4N4O2 |
Mol. Mass. | 518.5463 |
SMILES | C[C@H](C(N)=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N[C@@H](CC(C)(C)F)C(=O)NC1(CC1)C#N)C(F)(F)F |r| |
Structure |
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