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TargetCathepsin K
LigandBDBM50306307
Substrate/Competitorn/a
Meas. Tech.ChEMBL_609281 (CHEMBL1070042)
IC50 0.2±n/a nM
Citation Isabel, EBateman, KPChauret, NCromlish, WDesmarais, SDuong, le TFalgueyret, JPGauthier, JYLamontagne, SLau, CKLéger, SLeRiche, TLévesque, JFLi, CSMassé, FMcKay, DJMellon, CNicoll-Griffith, DAOballa, RMPercival, MDRiendeau, DRobichaud, JRodan, GARodan, SBSeto, CThérien, MTruong, VLWesolowski, GYoung, RNZamboni, RBlack, WC The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett20:887-92 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50306307
n/a
NameBDBM50306307
Synonyms:(S)-2-((S)-1-(4'-((S)-1-amino-1-oxopropan-2-yl)biphenyl-4-yl)-2,2,2-trifluoroethylamino)-N-(1-cyanocyclopropyl)-4-fluoro-4-methylpentanamide | CHEMBL597426
TypeSmall organic molecule
Emp. Form.C27H30F4N4O2
Mol. Mass.518.5463
SMILESC[C@H](C(N)=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N[C@@H](CC(C)(C)F)C(=O)NC1(CC1)C#N)C(F)(F)F |r|
Structure
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