| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
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| Ligand | BDBM50306683 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_611565 (CHEMBL1066409) |
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| IC50 | >50000±n/a nM |
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| Citation |  Nishii, H; Chiba, T; Morikami, K; Fukami, TA; Sakamoto, H; Ko, K; Koyano, H Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett20:1405-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase Yes |
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| Name: | Tyrosine-protein kinase Yes |
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| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
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| Type: | Protein |
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| Mol. Mass.: | 60801.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07947 |
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| Residue: | 543 |
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| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
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| BDBM50306683 |
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| n/a |
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| Name | BDBM50306683 |
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| Synonyms: | (R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinoline | CHEMBL600795 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Cl2FNO |
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| Mol. Mass. | 336.188 |
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| SMILES | C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl |r| |
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| Structure | 
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