| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
|---|
| Ligand | BDBM50306684 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_611558 (CHEMBL1066402) |
|---|
| IC50 | 25000±n/a nM |
|---|
| Citation |  Nishii, H; Chiba, T; Morikami, K; Fukami, TA; Sakamoto, H; Ko, K; Koyano, H Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett20:1405-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Fyn |
|---|
| Name: | Tyrosine-protein kinase Fyn |
|---|
| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60762.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06241 |
|---|
| Residue: | 537 |
|---|
| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
|
|
|
|---|
| BDBM50306684 |
|---|
| n/a |
|---|
| Name | BDBM50306684 |
|---|
| Synonyms: | 2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide | CHEMBL602472 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17Cl2FN2O2 |
|---|
| Mol. Mass. | 419.276 |
|---|
| SMILES | C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl |r| |
|---|
| Structure | 
|
|---|
Search and Browse
