Ki Summary

Reaction Details

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Target

Leukocyte tyrosine kinase receptor

Ligand

BDBM50306684

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_611555 (CHEMBL1066399)

IC50

10000±n/a nM

Citation

Nishii, H; Chiba, T; Morikami, K; Fukami, TA; Sakamoto, H; Ko, K; Koyano, H Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett20:1405-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Leukocyte tyrosine kinase receptor

Name:

Leukocyte tyrosine kinase receptor

Synonyms:

LTK | LTK_HUMAN | TYK1

Type:

PROTEIN

Mol. Mass.:

91679.76

Organism:

Homo sapiens (Human)

Description:

ChEMBL_586334

Residue:

864

Sequence:

MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
SSGLKPLKSRGLQPQNLWNPTYRS

BDBM50306684

n/a

Name

BDBM50306684

Synonyms:

2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide | CHEMBL602472

Type

Small organic molecule

Emp. Form.

C21H17Cl2FN2O2

Mol. Mass.

419.276

SMILES

C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl |r|

Structure