Reaction Details |
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Target | Cyclin-dependent kinase 1 |
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Ligand | BDBM50197834 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_609003 (CHEMBL1073145) |
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IC50 | 214±n/a nM |
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Citation | Hegde, VR; Borges, S; Patel, M; Das, PR; Wu, B; Gullo, VP; Chan, TM New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorg Med Chem Lett20:1344-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 1 |
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Name: | Cyclin-dependent kinase 1 |
Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 34101.08 |
Organism: | Homo sapiens (Human) |
Description: | P06493 |
Residue: | 297 |
Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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BDBM50197834 |
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n/a |
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Name | BDBM50197834 |
Synonyms: | 2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one | CHEMBL388956 | SCH-546909 | aristolactam AIIIa | aristololactam A IIIa |
Type | Small organic molecule |
Emp. Form. | C16H11NO4 |
Mol. Mass. | 281.2628 |
SMILES | COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 |
Structure |
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