| Reaction Details |
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 | Report a problem with these data |
| Target | Monoacylglycerol lipase ABHD6 |
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| Ligand | BDBM50307073 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609360 (CHEMBL1072746) |
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| IC50 | 2110±n/a nM |
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| Citation |  Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem53:1830-42 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoacylglycerol lipase ABHD6 |
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| Name: | Monoacylglycerol lipase ABHD6 |
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| Synonyms: | ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6 |
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| Type: | Single-pass type II membrane protein; hydrolase |
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| Mol. Mass.: | 38216.17 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells. |
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| Residue: | 336 |
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| Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYST
DNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
SFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEV
LENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
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| BDBM50307073 |
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| n/a |
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| Name | BDBM50307073 |
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| Synonyms: | 4-nitrophenyl 4-(hydroxybis(4-methoxyphenyl)methyl)piperidine-1-carboxylate | CHEMBL604758 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28N2O7 |
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| Mol. Mass. | 492.5204 |
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| SMILES | COc1ccc(cc1)C(O)(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)c1ccc(OC)cc1 |
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| Structure | 
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