| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monoglyceride lipase |
|---|
| Ligand | BDBM50307072 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_609359 (CHEMBL1072745) |
|---|
| IC50 | 15±n/a nM |
|---|
| Citation |  Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem53:1830-42 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monoglyceride lipase |
|---|
| Name: | Monoglyceride lipase |
|---|
| Synonyms: | MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL) |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 33391.67 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
|---|
| Residue: | 303 |
|---|
| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
|
|
|
|---|
| BDBM50307072 |
|---|
| n/a |
|---|
| Name | BDBM50307072 |
|---|
| Synonyms: | 4-Nitrophenyl 4-(Biphenyl-4-ylmethyl)piperazine-1-carboxylate | CHEMBL602281 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23N3O4 |
|---|
| Mol. Mass. | 417.4571 |
|---|
| SMILES | [O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3ccc(cc3)-c3ccccc3)CC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
