| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride Lipase (MGL) |
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| Ligand | BDBM50307085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609359 |
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| IC50 | 50±n/a nM |
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| Citation |  Long JZ; Jin X; Adibekian A; Li W; Cravatt BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem 53:1830-42 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride Lipase (MGL) |
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| Name: | Monoglyceride Lipase (MGL) |
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| Synonyms: | MAG lipase | Monoacylglycerol lipase |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33391.67 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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| BDBM50307085 |
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| n/a |
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| Name | BDBM50307085 |
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| Synonyms: | 4-Nitrophenyl 4-((5-Phenylthiophen-2-yl)methyl)piperazine-1-carboxylate | CHEMBL601243 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N3O4S |
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| Mol. Mass. | 423.485 |
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| SMILES | [O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3ccc(s3)-c3ccccc3)CC2)cc1 |
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| Structure | 
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