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TargetMonoglyceride lipase
LigandBDBM50307081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_609359 (CHEMBL1072745)
IC50 70±n/a nM
Citation Long, JZJin, XAdibekian, ALi, WCravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem53:1830-42 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monoglyceride lipase
Name:Monoglyceride lipase
Synonyms:MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:Hydrolase
Mol. Mass.:33391.67
Organism:Mus musculus (mouse)
Description:Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50307081
n/a
NameBDBM50307081
Synonyms:4-Nitrophenyl 4-((5-(2-(Trifluoromethoxy)phenyl)furan-2-yl)methyl)piperazine-1-carboxylate | CHEMBL604948
TypeSmall organic molecule
Emp. Form.C23H20F3N3O6
Mol. Mass.491.4166
SMILES[O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3ccc(o3)-c3ccccc3OC(F)(F)F)CC2)cc1
Structure
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