| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50307077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609359 (CHEMBL1072745) |
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| IC50 | 1300±n/a nM |
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| Citation |  Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem53:1830-42 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33391.67 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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| BDBM50307077 |
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| n/a |
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| Name | BDBM50307077 |
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| Synonyms: | 4-Nitrophenyl 4-(Bis(3,4-dimethoxyphenyl)(hydroxy)methyl)-piperidine-1-carboxylate | CHEMBL599726 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N2O9 |
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| Mol. Mass. | 552.5724 |
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| SMILES | COc1ccc(cc1OC)C(O)(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)c1ccc(OC)c(OC)c1 |
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| Structure | 
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