| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monoacylglycerol lipase ABHD6 |
|---|
| Ligand | BDBM50307090 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_609360 (CHEMBL1072746) |
|---|
| IC50 | 180±n/a nM |
|---|
| Citation |  Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem53:1830-42 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monoacylglycerol lipase ABHD6 |
|---|
| Name: | Monoacylglycerol lipase ABHD6 |
|---|
| Synonyms: | ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6 |
|---|
| Type: | Single-pass type II membrane protein; hydrolase |
|---|
| Mol. Mass.: | 38216.17 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells. |
|---|
| Residue: | 336 |
|---|
| Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYST
DNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
SFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEV
LENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
|
|
|
|---|
| BDBM50307090 |
|---|
| n/a |
|---|
| Name | BDBM50307090 |
|---|
| Synonyms: | 4-Nitrophenyl 4-(Bis(4-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate | CHEMBL599731 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22Cl2N2O5 |
|---|
| Mol. Mass. | 501.359 |
|---|
| SMILES | OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
