| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM50307243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610341 (CHEMBL1072073) |
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| IC50 | 5.7±n/a nM |
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| Citation |  Roumen, L; Peeters, JW; Emmen, JM; Beugels, IP; Custers, EM; de Gooyer, M; Plate, R; Pieterse, K; Hilbers, PA; Smits, JF; Vekemans, JA; Leysen, D; Ottenheijm, HC; Janssen, HM; Hermans, JJ Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem53:1712-25 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM50307243 |
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| n/a |
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| Name | BDBM50307243 |
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| Synonyms: | 1-(4-Cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole | CHEMBL610513 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15N3 |
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| Mol. Mass. | 273.3318 |
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| SMILES | Cc1ccccc1-c1cncn1Cc1ccc(cc1)C#N |
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| Structure | 
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