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TargetProstaglandin E2 receptor EP3 subtype
LigandBDBM50307434
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610979 (CHEMBL1070310)
Ki 0.1±n/a nM
Citation Asada, MIwahashi, MObitsu, TKinoshita, ANakai, YOnoda, TNagase, TTanaka, MYamaura, YTakizawa, HYoshikawa, KSato, KNarita, MOhuchida, SNakai, HToda, M 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies. Bioorg Med Chem18:1641-58 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP3 subtype
Name:Prostaglandin E2 receptor EP3 subtype
Synonyms:PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3
Type:G-protein coupled receptor
Mol. Mass.:40092.50
Organism:Mus musculus (Mouse)
Description:n/a
Residue:365
Sequence:
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWS
DQLER
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50307434
n/a
NameBDBM50307434
Synonyms:3-{2-({[1-(3,5-Dimethylphenyl)-3-methylbutyl]amino}-carbonyl)-4-[(2-fluorophenoxy)methyl]phenyl}propanoic acid | CHEMBL603881
TypeSmall organic molecule
Emp. Form.C30H34FNO4
Mol. Mass.491.5937
SMILESCC(C)CC(NC(=O)c1cc(COc2ccccc2F)ccc1CCC(O)=O)c1cc(C)cc(C)c1
Structure
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