| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
|---|
| Ligand | BDBM50039547 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_611000 (CHEMBL1072376) |
|---|
| IC50 | 60±n/a nM |
|---|
| Citation |  Castilho, MS; Postigo, MP; Pereira, HM; Oliva, G; Andricopulo, AD Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: kinetic and structural studies. Bioorg Med Chem18:1421-7 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Purine nucleoside phosphorylase |
|---|
| Name: | Purine nucleoside phosphorylase |
|---|
| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32119.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 289 |
|---|
| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
|
|
|
|---|
| BDBM50039547 |
|---|
| n/a |
|---|
| Name | BDBM50039547 |
|---|
| Synonyms: | 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL310202 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H12N4O |
|---|
| Mol. Mass. | 240.2606 |
|---|
| SMILES | Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
