Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50124566 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_611006 (CHEMBL1072382) |
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IC50 | 242±n/a nM |
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Citation | Vu, AT; Cohn, ST; Zhang, P; Kim, CY; Mahaney, PE; Bray, JA; Johnston, GH; Koury, EJ; Cosmi, SA; Deecher, DC; Smith, VA; Harrison, JE; Leventhal, L; Whiteside, GT; Kennedy, JD; Trybulski, EJ 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors. J Med Chem53:2051-62 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50124566 |
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n/a |
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Name | BDBM50124566 |
Synonyms: | (R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine | 2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine | 2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine | 2-[2-ethoxyphenoxy(phenyl)methyl]-1,4-oxazinane | CHEMBL14370 | REBOXETINE | rac-syn-2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine |
Type | Small organic molecule |
Emp. Form. | C19H23NO3 |
Mol. Mass. | 313.3908 |
SMILES | CCOc1ccccc1OC(C1CNCCO1)c1ccccc1 |
Structure |
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