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TargetP2Y purinoceptor 12
LigandBDBM50307674
Substrate/Competitorn/a
Meas. Tech.ChEMBL_612285 (CHEMBL1064897)
Ki 3.6±n/a nM
Citation Parlow, JJBurney, MWCase, BLGirard, TJHall, KAHarris, PKHiebsch, RRHuff, RMLachance, RMMischke, DARapp, SRWoerndle, RSEnnis, MD Piperazinyl glutamate pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. J Med Chem53:2010-37 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 12
Name:P2Y purinoceptor 12
Synonyms:ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:Enzyme
Mol. Mass.:39458.48
Organism:Homo sapiens (Human)
Description:Q9H244
Residue:342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50307674
n/a
NameBDBM50307674
Synonyms:(4S)4-[({4-[(1-Acetylpiperidin-4-ylo)xy]-6-phenylpyridin-2-yl}carbonyl)mino]-5-oxo-5-{4-[(pentyloxy)carbonyl]piperazin-1-yl}pentanoicAcid | CHEMBL579081
TypeSmall organic molecule
Emp. Form.C34H45N5O9
Mol. Mass.667.7492
SMILESCCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(OC2CCN(CC2)C(=O)OC)cc(n1)-c1ccccc1 |r|
Structure
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