| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit |
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| Ligand | BDBM50307880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612856 (CHEMBL1067545) |
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| IC50 | 883±n/a nM |
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| Citation |  Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Ménard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring. J Med Chem53:1964-78 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit |
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| Name: | Mast/stem cell growth factor receptor Kit |
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| Synonyms: | CD117 antigen | CD_antigen=CD117 | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (cKIT) | Proto-oncogene c-Kit | Proto-oncogene tyrosine-protein kinase Kit | SCFR | Stem cell growth factor receptor | Tyrosine Kinase c-Kit | Tyrosine-protein kinase Kit | Tyrosine-protein kinase Kit (c-Kit) | c-kit | p-145 c-kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
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| Type: | Protein |
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| Mol. Mass.: | 109869.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10721 |
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| Residue: | 976 |
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| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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| BDBM50307880 |
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| n/a |
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| Name | BDBM50307880 |
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| Synonyms: | CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N5O3 |
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| Mol. Mass. | 467.5191 |
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| SMILES | CC(C)(C)c1cc(NC(=O)c2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1 |
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| Structure | 
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