| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase |
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| Ligand | BDBM50307956 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_608352 (CHEMBL1074386) |
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| IC50 | 3.8±n/a nM |
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| Citation |  McHardy, T; Caldwell, JJ; Cheung, KM; Hunter, LJ; Taylor, K; Rowlands, M; Ruddle, R; Henley, A; de Haven Brandon, A; Valenti, M; Davies, TG; Fazal, L; Seavers, L; Raynaud, FI; Eccles, SA; Aherne, GW; Garrett, MD; Collins, I Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). J Med Chem53:2239-49 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-alpha serine/threonine-protein kinase |
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| Name: | RAC-alpha serine/threonine-protein kinase |
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| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55681.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31749 |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM50307956 |
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| n/a |
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| Name | BDBM50307956 |
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| Synonyms: | 4-Amino-N-(2,4-dichlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide | CHEMBL599849 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20Cl2N6O |
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| Mol. Mass. | 419.308 |
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| SMILES | NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)NCc1ccc(Cl)cc1Cl |
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| Structure | 
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