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TargetRAC-beta serine/threonine-protein kinase
LigandBDBM50307964
Substrate/Competitorn/a
Meas. Tech.ChEMBL_608104 (CHEMBL1072809)
IC50 11±n/a nM
Citation McHardy, TCaldwell, JJCheung, KMHunter, LJTaylor, KRowlands, MRuddle, RHenley, Ade Haven Brandon, AValenti, MDavies, TGFazal, LSeavers, LRaynaud, FIEccles, SAAherne, GWGarrett, MDCollins, I Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). J Med Chem53:2239-49 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAC-beta serine/threonine-protein kinase
Name:RAC-beta serine/threonine-protein kinase
Synonyms:AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:Enzyme
Mol. Mass.:55766.64
Organism:Homo sapiens (Human)
Description:n/a
Residue:481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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BDBM50307964
n/a
NameBDBM50307964
Synonyms:4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(4-(trifluoromethyl)-benzyl)-piperidine-4-carboxamide | CHEMBL599847
TypeSmall organic molecule
Emp. Form.C20H21F3N6O
Mol. Mass.418.4155
SMILESNC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)NCc1ccc(cc1)C(F)(F)F
Structure
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