| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50214707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_613437 (CHEMBL1069548) |
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| Ki | 1±n/a nM |
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| Citation |  Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs. Bioorg Med Chem18:2275-84 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50214707 |
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| n/a |
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| Name | BDBM50214707 |
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| Synonyms: | 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine | CHEMBL236709 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15F2N4O4P |
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| Mol. Mass. | 336.2318 |
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| SMILES | Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 |
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| Structure | 
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