| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Ligand | BDBM50308557 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_613562 (CHEMBL1074188) |
|---|
| IC50 | >2000±n/a nM |
|---|
| Citation |  Hughes, RO; Rogier, DJ; Jacobsen, EJ; Walker, JK; Macinnes, A; Bond, BR; Zhang, LL; Yu, Y; Zheng, Y; Rumsey, JM; Walgren, JL; Curtiss, SW; Fobian, YM; Heasley, SE; Cubbage, JW; Moon, JB; Brown, DL; Acker, BA; Maddux, TM; Tollefson, MB; Mischke, BV; Owen, DR; Freskos, JN; Molyneaux, JM; Benson, AG; Blevis-Bal, RM Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5). J Med Chem53:2656-60 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 79875.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q08493 |
|---|
| Residue: | 712 |
|---|
| Sequence: | MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
|
|
|
|---|
| BDBM50308557 |
|---|
| n/a |
|---|
| Name | BDBM50308557 |
|---|
| Synonyms: | 3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)pyrido[3,4-b]pyrazin-2(1H)-one | CHEMBL591501 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H32N6O4 |
|---|
| Mol. Mass. | 468.5487 |
|---|
| SMILES | CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
