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Target11-beta-hydroxysteroid dehydrogenase 2
LigandBDBM50233538
Substrate/Competitorn/a
Meas. Tech.ChEMBL_607152
IC50 360±n/a nM
Citation Beseda ICzollner LShah PSKhunt RGaware RKosma PStanetty CDel Ruiz-Ruiz MCAmer HMereiter KDa Cunha TOdermatt AClassen-Houben DJordis U Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorg Med Chem 18:433-54 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 2
Name:11-beta-hydroxysteroid dehydrogenase 2
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:43740.05
Organism:Rattus norvegicus
Description:ChEMBL_735659
Residue:400
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPG
ALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELS
PVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYI
EHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRR
RFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL
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  Blast E-value cutoff:
BDBM50233538
n/a
NameBDBM50233538
Synonyms:18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoolean-12-en-30-oic acid | CHEMBL230006 | glycyrrhetinic acid
TypeSmall organic molecule
Emp. Form.C30H46O4
Mol. Mass.470.6838
SMILESCC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |r,t:19|
Structure
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