| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonyl reductase [NADPH] 1 |
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| Ligand | BDBM50308751 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607771 (CHEMBL1068742) |
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| IC50 | 13000±n/a nM |
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| Citation |  Berhe, S; Slupe, A; Luster, C; Charlier, HA; Warner, DL; Zalkow, LH; Burgess, EM; Enwerem, NM; Bakare, O Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase. Bioorg Med Chem18:134-41 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonyl reductase [NADPH] 1 |
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| Name: | Carbonyl reductase [NADPH] 1 |
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| Synonyms: | CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30380.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_607770 |
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| Residue: | 277 |
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| Sequence: | MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
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| BDBM50308751 |
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| n/a |
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| Name | BDBM50308751 |
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| Synonyms: | 3-(methyl-N-ethylcarbamate)-6-(N0-ethylphenylamino)indazol-4,7-dione | CHEMBL589095 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O4 |
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| Mol. Mass. | 368.3865 |
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| SMILES | CCN(c1ccccc1)c1cc(O)c2c(CC=NC(=O)OC)n[nH]c2c1O |w:16.16| |
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| Structure | 
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