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TargetProstaglandin D2 receptor 2
LigandBDBM50309316
Substrate/Competitorn/a
Meas. Tech.ChEMBL_609122 (CHEMBL1066570)
IC50 5.3±n/a nM
Citation Grimstrup, MRist, ØReceveur, JMFrimurer, TMUlven, TMathiesen, JMKostenis, EHögberg, T Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2. Bioorg Med Chem Lett20:1181-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM50309316
n/a
NameBDBM50309316
Synonyms:2-(2-(bis(4-fluorophenyl)methyl)-4-(pyridin-4-yl)thiazol-5-yl)acetic acid | CHEMBL602124
TypeSmall organic molecule
Emp. Form.C23H16F2N2O2S
Mol. Mass.422.447
SMILESOC(=O)Cc1sc(nc1-c1ccncc1)C(c1ccc(F)cc1)c1ccc(F)cc1
Structure
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