| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-1 |
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| Ligand | BDBM29590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_611473 (CHEMBL1069455) |
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| IC50 | 96200±n/a nM |
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| Citation |  Pasco, MY; Rotili, D; Altucci, L; Farina, F; Rouleau, GA; Mai, A; Néri, C Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J Med Chem53:1407-11 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-1 |
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| Name: | NAD-dependent protein deacetylase sirtuin-1 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
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| Type: | Developmental protein; hydrolase |
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| Mol. Mass.: | 81626.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 747 |
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| Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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| BDBM29590 |
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| n/a |
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| Name | BDBM29590 |
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| Synonyms: | 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL86537 | splitomicin |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10O2 |
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| Mol. Mass. | 198.2173 |
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| SMILES | O=C1CCc2c(O1)ccc1ccccc21 |
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| Structure | 
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