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TargetNeuronal acetylcholine receptor subunit alpha-7
LigandBDBM50309884
Substrate/Competitorn/a
Meas. Tech.ChEMBL_611542 (CHEMBL1066386)
Ki 119±n/a nM
Citation O'Donnell, CJ; Rogers, BN; Bronk, BS; Bryce, DK; Coe, JW; Cook, KK; Duplantier, AJ; Evrard, E; Hajós, M; Hoffmann, WE; Hurst, RS; Maklad, N; Mather, RJ; McLean, S; Nedza, FM; O'Neill, BT; Peng, L; Qian, W; Rottas, MM; Sands, SB; Schmidt, AW; Shrikhande, AV; Spracklin, DK; Wong, DF; Zhang, A; Zhang, L Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. J Med Chem53:1222-37 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-7
Name:Neuronal acetylcholine receptor subunit alpha-7
Synonyms:ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:Enzyme
Mol. Mass.:56502.44
Organism:Rattus norvegicus (Rat)
Description:Q05941
Residue:502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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  Blast E-value cutoff:
BDBM50309884
n/a
NameBDBM50309884
Synonyms:2-(6-(Pyridin-3-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane | CHEMBL597687
TypeSmall organic molecule
Emp. Form.C18H19N5O
Mol. Mass.321.3764
SMILESC1CN2CCC1N(CC2)c1nc2ncc(cc2o1)-c1cccnc1 |TLB:9:6:0.1:4.3,(-8.88,-.92,;-9.5,-2.06,;-9.42,-3.76,;-10.43,-4.47,;-10.12,-3.03,;-8.82,-2.33,;-7.41,-2.95,;-7.05,-4.42,;-8.05,-3.7,;-6.09,-2.18,;-4.59,-2.59,;-3.74,-1.31,;-2.22,-1.07,;-1.65,.37,;-2.63,1.57,;-4.15,1.33,;-4.71,-.1,;-6.15,-.65,;-2.15,3.05,;-3.19,4.2,;-2.71,5.67,;-1.19,6,;-.15,4.85,;-.63,3.37,)|
Structure
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