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TargetNeuronal acetylcholine receptor subunit alpha-7
LigandBDBM50309887
Substrate/Competitorn/a
Meas. Tech.ChEMBL_611542 (CHEMBL1066386)
Ki 15.3±n/a nM
Citation O'Donnell, CJRogers, BNBronk, BSBryce, DKCoe, JWCook, KKDuplantier, AJEvrard, EHajós, MHoffmann, WEHurst, RSMaklad, NMather, RJMcLean, SNedza, FMO'Neill, BTPeng, LQian, WRottas, MMSands, SBSchmidt, AWShrikhande, AVSpracklin, DKWong, DFZhang, AZhang, L Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. J Med Chem53:1222-37 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-7
Name:Neuronal acetylcholine receptor subunit alpha-7
Synonyms:ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:Enzyme
Mol. Mass.:56502.44
Organism:Rattus norvegicus (Rat)
Description:Q05941
Residue:502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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  Blast E-value cutoff:
BDBM50309887
n/a
NameBDBM50309887
Synonyms:4-(6-Fluoro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane | CHEMBL597688
TypeSmall organic molecule
Emp. Form.C14H17FN4O
Mol. Mass.276.3094
SMILESCc1nc2nc(oc2cc1F)N1CCN2CCC1CC2 |TLB:5:11:16.15:18.19,(31.85,-.7,;30.32,-.94,;29.76,-2.38,;28.23,-2.62,;27.38,-3.9,;25.89,-3.49,;25.83,-1.95,;27.27,-1.41,;27.82,.03,;29.35,.27,;29.91,1.72,;24.56,-4.26,;24.92,-5.73,;23.92,-5.01,;22.54,-5.08,;22.47,-3.37,;23.08,-2.23,;23.15,-3.64,;21.85,-4.34,;21.55,-5.78,)|
Structure
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