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TargetCannabinoid receptor 1
LigandBDBM50310044
Substrate/Competitorn/a
Meas. Tech.ChEMBL_612189
IC50 14.2±n/a nM
Citation Seo HJKim MJLee SHLee SHJung MEKim MSAhn KKim JLee J Synthesis and structure-activity relationship of 1,2,4-triazole-containing diarylpyrazolyl carboxamide as CB1 cannabinoid receptor-ligand. Bioorg Med Chem 18:1149-62 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | Cannabinoid CB1 receptor | Cannabinoid receptor 1 (CB1)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52856.55
Organism:Rattus norvegicus (rat)
Description:P20272
Residue:473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAI
AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHV
FHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCL
MWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILW
KAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPL
LAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50310044
n/a
NameBDBM50310044
Synonyms:4-((1H-1,2,4-Triazol-1-yl)methyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-((1R,4R)-4-methylcyclohexyl)-1H-pyrazole-3-carboxamide | CHEMBL598091
TypeSmall organic molecule
Emp. Form.C26H25Cl3N6O
Mol. Mass.543.875
SMILESC[C@H]1CC[C@@H](CC1)NC(=O)c1nn(c(c1Cn1cncn1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl |r,wU:4.7,wD:1.0,(26.91,-26.66,;25.37,-26.65,;24.61,-25.32,;23.06,-25.31,;22.3,-26.64,;23.06,-27.98,;24.59,-27.98,;20.76,-26.64,;19.98,-25.31,;20.75,-23.97,;18.44,-25.31,;17.54,-26.56,;16.08,-26.1,;16.07,-24.55,;17.53,-24.07,;18.14,-22.65,;17.21,-21.42,;15.67,-21.45,;15.17,-19.99,;16.4,-19.07,;17.66,-19.95,;14.73,-23.81,;14.7,-22.27,;13.35,-21.53,;12.03,-22.33,;10.68,-21.59,;12.07,-23.87,;13.42,-24.61,;14.75,-26.87,;13.41,-26.11,;12.09,-26.88,;12.08,-28.43,;10.75,-29.19,;13.41,-29.2,;14.76,-28.43,;16.09,-29.19,)|
Structure
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