| Reaction Details |
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 | Report a problem with these data |
| Target | Antithrombin-III |
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| Ligand | BDBM50310300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607976 (CHEMBL1072392) |
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| IC50 | >3000000±n/a nM |
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| Citation |  El-Ayache, NC; Li, SH; Warnock, M; Lawrence, DA; Emal, CD Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett20:966-70 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Antithrombin-III |
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| Name: | Antithrombin-III |
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| Synonyms: | ANT3_HUMAN | AT3 | ATIII | Antithrombin-III | Antithrombin-III precursor | Coagulation factor X/antithrombin III | SERPINC1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52602.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_35871 |
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| Residue: | 464 |
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| Sequence: | MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
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| BDBM50310300 |
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| n/a |
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| Name | BDBM50310300 |
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| Synonyms: | CHEMBL606451 | N,N'-(ethane-1,2-diyl)bis(3,4-dihydroxybenzenesulfonamide) | US9120744, CDE-021 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O8S2 |
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| Mol. Mass. | 404.415 |
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| SMILES | Oc1ccc(cc1O)S(=O)(=O)NCCNS(=O)(=O)c1ccc(O)c(O)c1 |
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| Structure | 
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