Reaction Details | |||
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Target | Melanocortin receptor 4 | ||
Ligand | BDBM50310326 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_608234 (CHEMBL1072423) | ||
EC50 | 11±n/a nM | ||
Citation | Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorg Med Chem18:580-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocortin receptor 4 | |||
Name: | Melanocortin receptor 4 | ||
Synonyms: | MC4-R | MC4R_MOUSE | Mc4r | ||
Type: | PROTEIN | ||
Mol. Mass.: | 36964.43 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_1498850 | ||
Residue: | 332 | ||
Sequence: |
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BDBM50310326 | |||
n/a | |||
Name | BDBM50310326 | ||
Synonyms: | (S)-2-(2-(2-(2-acetamido-N-benzylacetamido)-N-benzylacetamido)acetamido)-N-((S)-1-(2-amino-2-oxoethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide | CHEMBL589308 | ||
Type | Small organic molecule | ||
Emp. Form. | C41H51N11O7 | ||
Mol. Mass. | 809.9131 | ||
SMILES | CC(=O)NCC(=O)N(CC(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1)Cc1ccccc1 |r,wU:16.15,wD:27.26,(-7.77,-25.68,;-6.43,-26.44,;-6.43,-27.98,;-5.1,-25.68,;-3.76,-26.44,;-2.43,-25.68,;-2.43,-24.14,;-1.09,-26.44,;.24,-25.68,;1.57,-26.44,;1.57,-27.98,;2.91,-25.68,;4.24,-26.44,;5.58,-25.68,;5.58,-24.14,;6.91,-26.44,;8.25,-25.68,;8.25,-24.14,;9.58,-23.36,;9.58,-21.82,;10.91,-21.05,;10.91,-19.51,;12.25,-18.74,;9.58,-18.74,;9.58,-26.44,;9.58,-27.98,;10.91,-25.68,;12.25,-26.44,;12.25,-27.98,;13.59,-28.76,;14.82,-27.82,;16.09,-28.7,;15.64,-30.18,;16.43,-31.49,;15.7,-32.83,;14.15,-32.87,;13.36,-31.55,;14.11,-30.2,;13.58,-25.68,;13.58,-24.14,;14.92,-26.44,;16.25,-25.68,;17.59,-26.44,;18.92,-25.68,;17.59,-27.98,;2.91,-24.14,;1.57,-23.36,;1.57,-21.82,;.25,-21.05,;-1.09,-21.82,;-1.08,-23.37,;.25,-24.13,;-1.09,-27.98,;-2.43,-28.76,;-3.76,-27.98,;-5.1,-28.75,;-5.1,-30.29,;-3.75,-31.06,;-2.42,-30.29,)| | ||
Structure |