Reaction Details | |||
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Target | Melanocyte-stimulating hormone receptor | ||
Ligand | BDBM50310325 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_608232 (CHEMBL1072421) | ||
EC50 | 120±n/a nM | ||
Citation | Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorg Med Chem18:580-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocyte-stimulating hormone receptor | |||
Name: | Melanocyte-stimulating hormone receptor | ||
Synonyms: | MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r | ||
Type: | PROTEIN | ||
Mol. Mass.: | 35238.60 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_1498846 | ||
Residue: | 315 | ||
Sequence: |
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BDBM50310325 | |||
n/a | |||
Name | BDBM50310325 | ||
Synonyms: | 2-((6S,9S,12R)-6-((1H-indol-3-yl)methyl)-12,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,22-hexaoxo-1,4,7,10,13,16-hexaazacyclodocosan-4-yl)acetamide | CHEMBL602853 | ||
Type | Small organic molecule | ||
Emp. Form. | C45H57N11O7 | ||
Mol. Mass. | 864.0036 | ||
SMILES | NC(=O)CN1CCNC(=O)CCCCC(=O)N(Cc2ccccc2)CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |r,wU:28.29,39.41,wD:50.52,(33.21,-20.02,;31.88,-20.79,;31.88,-22.33,;30.54,-20.03,;29.22,-20.8,;27.88,-20.04,;27.87,-18.5,;26.54,-17.73,;26.49,-16.13,;27.82,-15.35,;25.16,-15.37,;23.83,-16.15,;22.49,-15.39,;21.16,-16.17,;21.17,-17.71,;22.51,-18.47,;19.84,-18.48,;18.5,-17.72,;18.49,-16.18,;19.83,-15.41,;19.82,-13.87,;18.48,-13.11,;17.14,-13.9,;17.16,-15.43,;19.85,-20.02,;18.52,-20.8,;17.18,-20.04,;18.53,-22.34,;19.88,-23.12,;19.86,-24.66,;18.52,-25.41,;17.2,-24.62,;15.86,-25.37,;15.84,-26.91,;17.17,-27.7,;18.51,-26.94,;21.21,-22.35,;21.21,-20.81,;22.55,-23.12,;23.88,-22.35,;23.88,-23.89,;22.55,-24.66,;22.55,-26.2,;21.22,-26.97,;21.22,-28.51,;19.88,-29.28,;22.55,-29.28,;25.21,-23.12,;25.21,-24.66,;26.55,-22.35,;27.88,-23.12,;27.88,-24.66,;29.22,-25.43,;30.45,-24.5,;31.71,-25.38,;31.27,-26.85,;32.06,-28.16,;31.32,-29.5,;29.78,-29.54,;28.99,-28.22,;29.73,-26.88,;29.22,-22.34,;30.56,-23.11,)| | ||
Structure |