Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50310315

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_608234 (CHEMBL1072423)

EC50

3300±n/a nM

Citation

Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorg Med Chem18:580-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

MC4-R | MC4R_MOUSE | Mc4r

Type:

PROTEIN

Mol. Mass.:

36964.43

Organism:

Mus musculus

Description:

ChEMBL_1498850

Residue:

332

Sequence:

MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY

BDBM50310315

n/a

Name

BDBM50310315

Synonyms:

2-((6S,9S,15S)-6-((1H-indol-3-yl)methyl)-13,15-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,22-hexaoxo-1,4,7,10,13,16-hexaazacyclodocosan-4-yl)acetamide | CHEMBL589517

Type

Small organic molecule

Emp. Form.

C45H57N11O7

Mol. Mass.

864.0036

SMILES

NC(=O)CN1CCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |r,wU:17.17,39.41,wD:50.52,(10.47,-37.67,;9.13,-38.44,;9.14,-39.98,;7.8,-37.67,;6.47,-38.45,;5.14,-37.68,;5.1,-36.08,;3.76,-35.32,;3.75,-33.78,;5.08,-33,;2.41,-33.02,;1.08,-33.8,;-.25,-33.03,;-1.58,-33.81,;-1.57,-35.35,;-.23,-36.11,;-2.9,-36.13,;-2.89,-37.67,;-4.23,-36.9,;-4.24,-35.36,;-2.91,-34.59,;-2.92,-33.05,;-4.26,-32.28,;-5.59,-33.07,;-5.57,-34.61,;-4.22,-38.45,;-5.56,-37.69,;-4.21,-39.99,;-5.54,-40.76,;-6.88,-40,;-6.87,-38.46,;-8.21,-37.69,;-9.54,-38.47,;-9.53,-40.02,;-8.2,-40.78,;-2.86,-40.77,;-1.53,-40,;-1.53,-38.46,;-.2,-40.77,;1.14,-40,;1.14,-41.54,;-.19,-42.31,;-.19,-43.85,;-1.53,-44.62,;-1.53,-46.16,;-2.86,-46.93,;-.19,-46.93,;2.47,-40.77,;2.47,-42.31,;3.8,-40,;5.14,-40.77,;5.14,-42.31,;6.47,-43.08,;7.71,-42.15,;8.97,-43.02,;8.53,-44.5,;9.32,-45.81,;8.58,-47.15,;7.04,-47.18,;6.25,-45.87,;6.99,-44.52,;6.48,-39.99,;7.81,-40.75,)|

Structure