Ki Summary

Reaction Details

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Target

chemokine (C-X-C motif) receptor 3

Ligand

BDBM50211114

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_619410

IC50

5±n/a nM

Citation

Liu J; Fu Z; Li AR; Johnson M; Zhu L; Marcus A; Danao J; Sullivan T; Tonn G; Collins T; Medina J Optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg Med Chem Lett 19:5114-8 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

chemokine (C-X-C motif) receptor 3

Name:

chemokine (C-X-C motif) receptor 3

Synonyms:

AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

40665.65

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

368

Sequence:

MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL

BDBM50211114

n/a

Name

BDBM50211114

Synonyms:

(-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide | (R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide | AMG-487 | CHEMBL397983

Type

Small organic molecule

Emp. Form.

C32H28F3N5O4

Mol. Mass.

603.591

SMILES

CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1 |r|

Structure