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TargetAurora kinase B
LigandBDBM26326
Substrate/Competitorn/a
Meas. Tech.ChEMBL_620386 (CHEMBL1112281)
IC50 31±n/a nM
Citation Zhong, MBui, MShen, WBaskaran, SAllen, DAElling, RAFlanagan, WMFung, ADHanan, EJHarris, SOHeumann, SAHoch, UIvy, SNJacobs, JWLam, SLee, HMcDowell, RSOslob, JDPurkey, HERomanowski, MJSilverman, JATangonan, BTTaverna, PYang, WYoburn, JCYu, CHZimmerman, KMO'Brien, TLew, W 2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett19:5158-61 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26326
n/a
NameBDBM26326
Synonyms:1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]urea | SN-314
TypeSmall organic molecule
Emp. Form.C18H15ClN6OS2
Mol. Mass.430.934
SMILESClc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: