Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAurora kinase A
LigandBDBM26315
Substrate/Competitorn/a
Meas. Tech.ChEMBL_620385 (CHEMBL1112280)
IC50 22±n/a nM
Citation Zhong, MBui, MShen, WBaskaran, SAllen, DAElling, RAFlanagan, WMFung, ADHanan, EJHarris, SOHeumann, SAHoch, UIvy, SNJacobs, JWLam, SLee, HMcDowell, RSOslob, JDPurkey, HERomanowski, MJSilverman, JATangonan, BTTaverna, PYang, WYoburn, JCYu, CHZimmerman, KMO'Brien, TLew, W 2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett19:5158-61 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26315
n/a
NameBDBM26315
Synonyms:3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]-1-[3-(trifluoromethyl)phenyl]urea | CHEMBL472193 | thieno[3,2-d]pyrimidine analogue, 10
TypeSmall organic molecule
Emp. Form.C19H15F3N6OS2
Mol. Mass.464.487
SMILESFC(F)(F)c1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: