Reaction Details |
| Report a problem with these data |
Target | Aurora kinase A |
---|
Ligand | BDBM26315 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_620385 (CHEMBL1112280) |
---|
IC50 | 22±n/a nM |
---|
Citation | Zhong, M; Bui, M; Shen, W; Baskaran, S; Allen, DA; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, SO; Heumann, SA; Hoch, U; Ivy, SN; Jacobs, JW; Lam, S; Lee, H; McDowell, RS; Oslob, JD; Purkey, HE; Romanowski, MJ; Silverman, JA; Tangonan, BT; Taverna, P; Yang, W; Yoburn, JC; Yu, CH; Zimmerman, KM; O'Brien, T; Lew, W 2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett19:5158-61 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aurora kinase A |
---|
Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
BDBM26315 |
---|
n/a |
---|
Name | BDBM26315 |
Synonyms: | 3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]-1-[3-(trifluoromethyl)phenyl]urea | CHEMBL472193 | thieno[3,2-d]pyrimidine analogue, 10 |
Type | Small organic molecule |
Emp. Form. | C19H15F3N6OS2 |
Mol. Mass. | 464.487 |
SMILES | FC(F)(F)c1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1 |
Structure |
|