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TargetC-C chemokine receptor type 5
LigandBDBM50310731
Substrate/Competitorn/a
Meas. Tech.ChEMBL_621115 (CHEMBL1113199)
IC50 7±n/a nM
Citation Rotstein, DMGabriel, SDMakra, FFilonova, LGleason, SBrotherton-Pleiss, CSetti, LQTrejo-Martin, ALee, EKSankuratri, SJi, CDerosier, ADioszegi, MHeilek, GJekle, ABerry, PWeller, PMau, CI Spiropiperidine CCR5 antagonists. Bioorg Med Chem Lett19:5401-6 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 5
Name:C-C chemokine receptor type 5
Synonyms:C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:Enzyme
Mol. Mass.:40540.21
Organism:Homo sapiens (Human)
Description:P51681
Residue:352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50310731
n/a
NameBDBM50310731
Synonyms:4-butyl-3-(cyclohexylmethyl)-8-(1-(4,6-dimethylpyrimidine-5-carbonyl)-4-methylpiperidin-4-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one | CHEMBL1077912
TypeSmall organic molecule
Emp. Form.C31H49N5O3
Mol. Mass.539.7525
SMILESCCCCC1N(CC2CCCCC2)C(=O)OC11CCN(CC1)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C
Structure
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