| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50310822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_621473 (CHEMBL1100034) |
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| IC50 | 3±n/a nM |
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| Citation |  Shen, HC; Ding, FX; Deng, Q; Xu, S; Chen, HS; Tong, X; Tong, V; Zhang, X; Chen, Y; Zhou, G; Pai, LY; Alonso-Galicia, M; Zhang, B; Roy, S; Tata, JR; Berger, JP; Colletti, SL Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett19:5314-20 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62337.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1465995 |
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| Residue: | 554 |
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| Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
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| BDBM50310822 |
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| n/a |
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| Name | BDBM50310822 |
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| Synonyms: | CHEMBL1078754 | methyl 3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3-yl)propanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25ClN2O3 |
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| Mol. Mass. | 400.899 |
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| SMILES | COC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1 |
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| Structure | 
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