| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha |
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| Ligand | BDBM50311409 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_622265 (CHEMBL1110410) |
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| IC50 | 5.5±n/a nM |
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| Citation |  Enkvist, E; Kriisa, M; Roben, M; Kadak, G; Raidaru, G; Uri, A Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases. Bioorg Med Chem Lett19:6098-101 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit alpha |
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| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
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| Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit |
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| Type: | Enzyme Catalytic Subunit |
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| Mol. Mass.: | 40598.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| BDBM50311409 |
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| n/a |
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| Name | BDBM50311409 |
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| Synonyms: | CHEMBL1077375 | N-((6R,9R,12R,15R,18R,21R,31R)-1-amino-31-(4-aminobutyl)-6-carbamoyl-9,12,15,18,21-pentakis(3-guanidinopropyl)-1-imino-8,11,14,17,20,23,30,33-octaoxo-2,7,10,13,16,19,22,29,32-nonaazaoctatriacontan-38-yl)-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C63H114N32O10S |
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| Mol. Mass. | 1511.853 |
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| SMILES | [#7]-[#6]-[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-c1ccc(s1)-c1ccnc(-[#7])n1)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#7])=O |r| |
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| Structure | 
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