| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxycytidine kinase |
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| Ligand | BDBM50311558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_618319 (CHEMBL1101183) |
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| IC50 | 6±n/a nM |
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| Citation |  Tarver, JE; Jessop, TC; Carlsen, M; Augeri, DJ; Fu, Q; Healy, JP; Heim-Riether, A; Xu, A; Taylor, JA; Shen, M; Keyes, PE; David Kimball, S; Yu, XC; Miranda, M; Liu, Q; Swaffield, JC; Nouraldeen, A; Wilson, AG; Finch, R; Jhaver, K; Foushee, AM; Anderson, S; Oravecz, T; Carson, KG 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase. Bioorg Med Chem Lett19:6780-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxycytidine kinase |
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| Name: | Deoxycytidine kinase |
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| Synonyms: | DCK | DCK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30510.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1437135 |
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| Residue: | 260 |
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| Sequence: | MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
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| BDBM50311558 |
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| n/a |
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| Name | BDBM50311558 |
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| Synonyms: | 5-fluoro-2-(1-(6-(2-fluorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine | CHEMBL1081901 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18F2N6O2 |
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| Mol. Mass. | 400.382 |
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| SMILES | Nc1nc(OC2CCN(CC2)c2cc(Oc3ccccc3F)ncn2)ncc1F |
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| Structure | 
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