| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxycytidine kinase |
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| Ligand | BDBM50311603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_618630 (CHEMBL1101518) |
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| IC50 | 21±n/a nM |
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| Citation |  Jessop, TC; Tarver, JE; Carlsen, M; Xu, A; Healy, JP; Heim-Riether, A; Fu, Q; Taylor, JA; Augeri, DJ; Shen, M; Stouch, TR; Swanson, RV; Tari, LW; Hunter, M; Hoffman, I; Keyes, PE; Yu, XC; Miranda, M; Liu, Q; Swaffield, JC; David Kimball, S; Nouraldeen, A; Wilson, AG; Foushee, AM; Jhaver, K; Finch, R; Anderson, S; Oravecz, T; Carson, KG Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett19:6784-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxycytidine kinase |
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| Name: | Deoxycytidine kinase |
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| Synonyms: | DCK | DCK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30510.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1437135 |
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| Residue: | 260 |
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| Sequence: | MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
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| BDBM50311603 |
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| n/a |
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| Name | BDBM50311603 |
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| Synonyms: | CHEMBL1079432 | N-((1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)-4'-chloro-2'-methylbiphenyl-3-sulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClFN4O3S |
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| Mol. Mass. | 476.951 |
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| SMILES | Cc1cc(Cl)ccc1-c1cccc(c1)S(=O)(=O)N[C@H]1CC[C@@H](C1)n1cc(F)c(N)nc1=O |r| |
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| Structure | 
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