| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Deoxycytidine kinase |
|---|
| Ligand | BDBM50311607 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_618630 (CHEMBL1101518) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Jessop, TC; Tarver, JE; Carlsen, M; Xu, A; Healy, JP; Heim-Riether, A; Fu, Q; Taylor, JA; Augeri, DJ; Shen, M; Stouch, TR; Swanson, RV; Tari, LW; Hunter, M; Hoffman, I; Keyes, PE; Yu, XC; Miranda, M; Liu, Q; Swaffield, JC; David Kimball, S; Nouraldeen, A; Wilson, AG; Foushee, AM; Jhaver, K; Finch, R; Anderson, S; Oravecz, T; Carson, KG Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett19:6784-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Deoxycytidine kinase |
|---|
| Name: | Deoxycytidine kinase |
|---|
| Synonyms: | DCK | DCK_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30510.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1437135 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
|
|
|
|---|
| BDBM50311607 |
|---|
| n/a |
|---|
| Name | BDBM50311607 |
|---|
| Synonyms: | CHEMBL1076274 | N-((1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)-3'-chlorobiphenyl-3-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20ClFN4O2 |
|---|
| Mol. Mass. | 426.871 |
|---|
| SMILES | Nc1nc(=O)n(cc1F)[C@H]1CC[C@@H](C1)NC(=O)c1cccc(c1)-c1cccc(Cl)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
