| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor p65 |
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| Ligand | BDBM50250510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_618973 (CHEMBL1100043) |
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| IC50 | 3200±n/a nM |
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| Citation |  Han, AR; Kim, JA; Lantvit, DD; Kardono, LB; Riswan, S; Chai, H; Carcache de Blanco, EJ; Farnsworth, NR; Swanson, SM; Kinghorn, AD Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod72:2028-31 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor p65 |
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| Name: | Transcription factor p65 |
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| Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60211.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04206 |
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| Residue: | 551 |
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| Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
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| BDBM50250510 |
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| n/a |
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| Name | BDBM50250510 |
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| Synonyms: | CHEMBL462879 | GARCINONE D |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28O7 |
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| Mol. Mass. | 428.4749 |
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| SMILES | [#6]-[#8]-c1c(-[#8])cc2oc3cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c3c(=O)c2c1-[#6]-[#6]C([#6])([#6])[#8] |
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| Structure | 
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