| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
|---|
| Ligand | BDBM50311954 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_619954 (CHEMBL1113996) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Shim, J; Eid, C; Lee, J; Liu, E; Chaudhary, D; Boschelli, DH Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett19:6575-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Fyn |
|---|
| Name: | Tyrosine-protein kinase Fyn |
|---|
| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60762.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06241 |
|---|
| Residue: | 537 |
|---|
| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
|
|
|
|---|
| BDBM50311954 |
|---|
| n/a |
|---|
| Name | BDBM50311954 |
|---|
| Synonyms: | 6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile | CHEMBL1080995 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H30N6O2S |
|---|
| Mol. Mass. | 526.653 |
|---|
| SMILES | CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2c(C)ncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
