Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50311983 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_620206 (CHEMBL1115841) | ||
| IC50 | 1±n/a nM | ||
| Citation |  Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Discovery of highly potent and selective type I B-Raf kinase inhibitors. Bioorg Med Chem Lett19:6571-4 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM50311983 | |||
| n/a | |||
| Name | BDBM50311983 | ||
| Synonyms: | (R)-3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-3-ylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol | CHEMBL1086871 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H28N6O | ||
| Mol. Mass. | 488.5829 | ||
| SMILES | Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(N[C@H]2CN3CCC2CC3)cc1)-c1ccncc1 |r,wU:21.23,(27.09,-49.36,;27.87,-48.04,;29.41,-48.05,;30.19,-46.72,;29.43,-45.38,;27.9,-45.37,;27.11,-46.7,;27.16,-44.03,;28.07,-42.79,;27.17,-41.54,;25.71,-42,;24.37,-41.24,;23.04,-42,;23.03,-43.54,;24.36,-44.31,;25.7,-43.54,;24.37,-39.7,;23.04,-38.93,;23.05,-37.39,;24.37,-36.62,;24.39,-35.08,;25.74,-34.33,;25.77,-32.78,;27.12,-32.02,;28.45,-32.82,;28.42,-34.36,;27.07,-35.12,;27.58,-33.8,;26.3,-33.23,;25.71,-37.38,;25.72,-38.93,;29.61,-42.8,;30.37,-44.14,;31.91,-44.15,;32.69,-42.82,;31.92,-41.48,;30.38,-41.47,)| | ||
| Structure | 
| ||