| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 1 |
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| Ligand | BDBM50312032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_620603 (CHEMBL1112064) |
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| Ki | 50±n/a nM |
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| Citation |  Sun, ZY; Zhu, Z; Ye, Y; McKittrick, B; Czarniecki, M; Greenlee, W; Mullins, D; Guzzi, M Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists. Bioorg Med Chem Lett19:6801-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 1 |
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| Name: | Neuropeptide Y receptor type 1 |
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| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44399.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y1 NPY1R HUMAN::P25929 |
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| Residue: | 384 |
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| Sequence: | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
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| BDBM50312032 |
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| n/a |
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| Name | BDBM50312032 |
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| Synonyms: | (+/-)-N-(4-(4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylamino)phenethyl)benzo[d]thiazol-2-amine | CHEMBL1080291 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4S2 |
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| Mol. Mass. | 382.545 |
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| SMILES | CC1CCSC(N1)=Nc1ccc(CCNc2nc3ccccc3s2)cc1 |w:7.8| |
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| Structure | 
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