| Reaction Details |
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 | Report a problem with these data |
| Target | Low molecular weight protein-tyrosine phosphatase A |
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| Ligand | BDBM50312266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_621991 (CHEMBL1106782) |
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| Ki | 3100±n/a nM |
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| Citation |  Rawls, KA; Lang, PT; Takeuchi, J; Imamura, S; Baguley, TD; Grundner, C; Alber, T; Ellman, JA Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett19:6851-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Low molecular weight protein-tyrosine phosphatase A |
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| Name: | Low molecular weight protein-tyrosine phosphatase A |
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| Synonyms: | PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA |
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| Type: | Hydrolase |
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| Mol. Mass.: | 17891.84 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 163 |
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| Sequence: | MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAG
VLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTH
ALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
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| BDBM50312266 |
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| n/a |
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| Name | BDBM50312266 |
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| Synonyms: | (4-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)phenyl)difluoromethylphosphonic acid | CHEMBL1081956 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11F8N2O4P |
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| Mol. Mass. | 478.2305 |
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| SMILES | OP(O)(=O)C(F)(F)c1ccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 |
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| Structure | 
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