| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50312624 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_616012 (CHEMBL1101056) |
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| IC50 | 8±n/a nM |
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| Citation |  He, R; Chen, Y; Chen, Y; Ougolkov, AV; Zhang, JS; Savoy, DN; Billadeau, DD; Kozikowski, AP Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents. J Med Chem53:1347-56 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50312624 |
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| n/a |
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| Name | BDBM50312624 |
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| Synonyms: | CHEMBL1091475 | Octanedioic Acid Hydroxyamide-{3-[1-(4-Iodophenyl)-1H-[1,2,3]triazol-4-yl]phenyl}amide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24IN5O3 |
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| Mol. Mass. | 533.3621 |
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| SMILES | ONC(=O)CCCCCCC(=O)Nc1cccc(c1)-c1cn(nn1)-c1ccc(I)cc1 |
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| Structure | 
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